Dating secretory endometrium

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Diagnostic algorithm for examination of endometrial biopsies Tissues not derived from the endometrium are commonly represented in endometrial biopsies. Ciliated cells are common in a normal cyclical endometrium. Epithelial metaplasias, especially squamous or mucinous in type, may coexist with hyperplasia or a carcinoma. The risk of developing an endometrioid adenocarcinoma after a diagnosis of atypical hyperplasia is difficult to ascertain, as, once atypical endometrial hyperplasia is diagnosed, it is treated either hormonally or more usually surgically. Bridging between adjacent glands, resulting in a cribriform pattern, as well as the presence of luminal necrosis with polymorph infiltration, suggests an adenocarcinoma.

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InBokhman 68 first proposed that there were two major variants of endometrial cancer—namely type 1 the prototype of which is endometrioid carcinoma and type 2 the prototype of which is serous carcinoma.

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My approach to the interpretation of endometrial biopsies and curettings

LH ratios in the follicular phase, low serum concentrations of progesterone and oestrogen in the luteal phase, and decreased response of the endometrium to progesterone have been implicated Soules et al. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Am J Surg Pathol 4 — Inflammation of the endometrium. Download all figures.

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